Promethazine HCl Oral Solution need to be made use of with warning in people with bone-marrow despair. Leukopenia and agranulocytosis are already documented, usually when Promethazine (Promethazine HCl) has been used in Affiliation with other recognised marrow-toxic agents.Promethazine HCl Oral Option is contraindicated in comatose states, As well